The wreck was centered near Mile Marker 831, between Taylor's Bayou and Hamshire Road in Jefferson County.
There were two confirmed fatalities. The Hispanic man and woman were in a 2007 Chevy SUV crushed under an 18-wheeler.
They are from Pearland, but their names have not been released pending the notification of their family.
Shortly before 3:30 this afternoon, Sergeant Chuck Havard with the Texas Department of Public Safety told Fox 4 that between 30 to 50 people have been taken to hospitals.